Leo Tomasevic
Tel.
Position
Research Fellow
Research Interests
I am interested in the sensory-motor system and in the intra- and inter-subject variability observed in brain function and structure. To perform my studies I use multimodal approaches combining electroencephalography (EEG) with other techniques, for example brain stimulation and magnetic resonance imaging (MRI). In addition, to investigate the inhibition/excitation balance, I take advantage of magnetic resonance spectroscopy (MRS) that can detect non-invasively, in the human living brain, concentrations of glutamate and GABA, main excitatory and inhibitory neurotransmitters respectively.
Research Groups
EEG group (Group Leader)
Brain Network Modulation group
Control of Movement group
Brain Stimulation group
Research area "Cognitive & Computational Neuroscience"
Research area "Precision Brain Stimulation"
Curriculum Vitae
Education
2014
PhD, Computing and Mathematics, University of Plymouth, UK
2008
Electronic Engineering at the University La Sapienza, Rome, Italy
Employments
2019 - Present
Research Fellow, DRCMR
2014 - 2019
Postdoc, DRCMR
2012 - 2014
Researcher: Italian National Research Council (CNR), Fatebenefratelli Hospital, Rome, Italy
2010 - 2012
Research Assistant: Italian National Research Council (CNR), Fatebenefratelli Hospital, Rome, Italy
2009 - 2010
Research Assistant: University Campus Bio-Medico, Fatebenefratelli Hospital, Rome, Italy
2008 - 2008
Administrative and coordination employee in SALCEF S.p.A. and representative in the project in Croatia Vinkovci to Tovarnik to State Border Railway Rehabilitations
Publications
Video Pitch: Presentation
Skoven CS, Tomasevic L, Kvitsiani D, Pakkenberg B, Dyrby TB, Siebner HR. Dose-response relationship between the variables of unilateral optogenetic stimulation and transcallosal evoked responses in rat motor cortex. Front Neurosci. 2022 Sep 23;16:968839. doi: 10.3389/fnins.2022.968839. PMID: 36213739; PMCID: PMC9539969.
Ver Loren van Themaat AH, Oranje B, Larsen KM, Tomasevic L, Korsgaard Johnsen L, Elgaard Thorup AA, Plessen KJ, Siebner HR, Nordentoft M. Mismatch negativity and P3a amplitude in children with familial high risk of schizophrenia or bipolar disorder - A Danish register-based EEG study. Schizophr Res. 2022 Aug;246:187-194. doi:10.1016/j.schres.2022.06.035. Epub 2022 Jul 5. PMID: 35797883.
Tomasevic L, Siebner HR, Thielscher A, Manganelli F, Pontillo G, Dubbioso R. Relationship between high-frequency activity in the cortical sensory and the motor hand areas, and their myelin content. Brain Stimul. 2022 May 4:S1935-861X(22)00078-X. doi: 10.1016/j.brs.2022.04.018. Epub ahead of print. PMID: 35525389
Dubbioso R, Striano P, Tomasevic L, Bilo L, Esposito M, Manganelli F, Coppola A. Abnormal sensorimotor cortex and thalamo-cortical networks in familial adult myoclonic epilepsy type 2: pathophysiology and diagnostic implications. Brain Commun. 2022 Feb 15;4(1):fcac037.
Bergmann TO, Tomasevic L, Siebner HR. Transcranial brain stimulation and EEG/MEG. The Oxford Handbook of Transcranial Stimulation, Second Edition. 2021 Aug.
Bernardo, P., Cobb, S., Coppola A., Tomasevic, L., Di Lazzaro, V., Bravaccio, C., Manganelli, F., Dubbioso, R. Neurophysiological Signatures of Motor Impairment in Patients with Rett Syndrome. Ann Neurol. 2020 Mar 4. doi: 10.1002/ana.25712.
Tashiro, S., Siebner, HR., Charalampaki, A., Göksu, C., Saturnino, GB., Thielscher, A., Tomasevic, L. Probing EEG activity in the targeted cortex after focal transcranial electrical stimulation. Brain stimul. 2020 May-Jun, 13(3):815-818. doi: 10.1016/j.brs.2020.02.015.
Siebner, HR., Conde, V., Tomasevic, L., Thielscher, A., Bergmann, TO. Distilling the essence of TMS-evoked EEG potentials (TEPs): A call for securing mechanistic specificity and experimental rigor. Brain Stimul. 2019 Apr 2. pii: S1935-861X(19)30184-6. doi: 10.1016/j.brs.2019.03.076. [Epub ahead of print] PubMed PMID: 30962028.
Dubbioso, R., Tomasevic, L. Need to find a signature of abnormal brain oscillations in task-specific focal dystonia. Clin Neurophysiol. 2019 Jun; 130 (6) : 1025-1026. doi: 10.1016/j.clinph.2019.04.002. Epub 2019 Apr 9. PubMed PMID: 30987887.
Madsen, KH., Karabanov, AN., Krohne, LG., Safeldt, MG., Tomasevic, L., Siebner, HR. No trace of phase: Corticomotor excitability is not tuned by phase of pericentral mu-rhythm. Brain Stimul. 2019 May 8. pii: S1935-861X(19)30212-8. doi: 10.1016/j.brs.2019.05.005. [Epub ahead of print] PubMed PMID: 31133479.
Tomasevic, L. and Siebner, HR., "Peak-projection algorithm to target the phase of cortical oscillations in real-time," 2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med), Split, 2018, pp. 1-2. doi: 10.23919/EMF-MED.2018.8526056
Conde, V., Tomasevic, L., Akopian I., Stanek, K., Saturnino, GB., Thielscher, A., Bergmann, TO, and Siebner, HR. The non-transcranial TMS-evoked potential is an inherent source of ambiguity in TMS-EEG studies. Neuroimage. 2018 Oct 19;185:300-312. doi: 10.1016/j.neuroimage.2018.10.052. [Epub ahead of print] PubMed PMID: 30347282.
Pellegrino, G., Tomasevic, L., Herz, DM., Larsen, KM., Siebner, HR. Theta Activity in the Left Dorsal Premotor Cortex During Action Re-Evaluation and Motor Reprogramming. Front Hum Neurosci. 2018 Sep 21;12:364. doi: 10.3389/fnhum.2018.00364. eCollection 2018. PubMed PMID: 30297991; PubMed Central PMCID: PMC6161550.
Tomasevic, L., Takemi, M., Siebner, HR.. Synchronizing the transcranial magnetic pulse with electroencephalographic recordings effectively reduces inter-trial variability of the pulse artefact. PLoS One. 2017 Sep 21;12(9):e0185154.
Pellegrino, G., Tombini, M., Curcio, G., Campana, C., Di Pino, G., Assenza, G., Tomasevic, L., Di Lazzaro, V. Slow Activity in Focal Epilepsy During Sleep and Wakefulness. Clin EEG Neurosci. 2016 Jun 10. pii: 1550059416652055. [Epub ahead of print] PubMed PMID: 27287223.
Cogliati Dezza, I.*, Zito, G.*, Tomasevic, L., Filippi, MM., Ghazaryan, A., Porcaro, C., Squitti, R., Ventriglia, M., Lupoi, D., Tecchio, F. Functional and structural balances of homologous sensorimotor regions in multiple sclerosis fatigue. J Neurol. 2014 Dec 19.
Zito, G., Luders, E., Tomasevic, L., Lupoi, D., Toga, AW., Thompson, PM., Rossini, PM., Filippi, MM., Tecchio, F. Inter-hemispheric functional connectivity changes with corpus callosum morphology in multiple sclerosis. Neuroscience. 2014 Apr 25;266:47-55.
Tomasevic, L.*, Giambattistelli, F.*, Pellegrino, G., Porcaro, C., Melgari, JM., Rossini, PM., Tecchio, F. The spontaneous fluctuation of the excitability of a single node modulates the internodes connectivity: a TMS-EEG study. Hum Brain Mapp. 2014 Apr;35(4):1740-9.
Salustri, C., Tecchio, F., Zappasodi, F., Tomasevic L, Ercolani, M., Moffa, F., Cassetta, E., Rossini, PM., Squitti, R. Sensorimotor Cortex Reorganization in Alzheimer's Disease and Metal Dysfunction: A MEG Study. Int J Alzheimers Dis. 2013;2013:638312.
Melgari, JM., Zappasodi, F., Porcaro, C., Tomasevic, L., Cassetta, E., Rossini, PM., Tecchio, F. Movement-induced uncoupling of primary sensory and motor areas in focal task-specific hand dystonia. Neuroscience. 2013 Oct 10;250:434-45.
Tecchio, F., Cancelli, A., Cottone, C., Tomasevic, L., Devigus, B., Zito, G., Ercolani, M., Carducci, F. Regional personalized electrodes to select transcranial current stimulation target. Front Hum Neurosci. 2013 Apr 22;7:131.
Porcaro, C., Coppola, G., Pierelli, F., Seri, S., Di Lorenzo, G., Tomasevic, L., Salustri, C., Tecchio, F. Multiple frequency functional connectivity in the hand somatosensory network: An EEG study. Clin Neurophysiol. 2013 Jan 7.
Graziadio, S., Tomasevic, L., Assenza, G., Tecchio, F., Eyre, JA. The myth of the 'unaffected' side after unilateral stroke: is reorganisation of the non-infarcted corticospinal system to re-establish balance the price for recovery? Exp Neurol. 2012 Dec;238(2):168-75.
Tomasevic, L.*, Pellegrino, G.*, Tombini, M., Assenza, G., Bravi, M., Sterzi, S., Giacobbe, V., Zollo, L., Guglielmelli, E., Cavallo, G., Vernieri, F., Tecchio, F. Inter-hemispheric coupling changes associate with motor improvements after robotic stroke rehabilitation. Restor Neurol Neurosci. 2012;30(6):497-510.
Tomasevic, L.*, Cottone, C.*, Porcaro, C., Filligoi, G., Tecchio, F. Physiological aging impacts the hemispheric balances of resting state primary somatosensory activities. Brain Topogr. 2013 Jan;26(1):186-99.
Tomasevic, L., Zito, G., Pasqualetti, P., Filippi, M., Landi, D., Ghazaryan, A., Lupoi, D., Porcaro, C., Bagnato, F., Rossini, P., Tecchio, F. Cortico-muscular coherence as an index of fatigue in multiple sclerosis. Mult Scler. 2013 Mar;19(3):334-43.
Graziadio, S., Basu, A., Tomasevic, L., Zappasodi, F., Tecchio, F., Eyre, JA. Developmental tuning and decay in senescence of oscillations linking the corticospinal system. J Neurosci. 2010 Mar 10;30(10):3663-74.