Frederiksen KS;Garde E;Skimminge A;Barkhof F;Scheltens P;van Straaten EC;Fazekas F;Baezner H;Verdelho A;Ferro JM;Erkinjuntti T;Jokinen H;Wahlund LO;O'Brien JT;Basile AM;Pantoni L;Inzitari D;Waldemar G
Corpus Callosum Tissue Loss and Development of Motor and Global Cognitive Impairment: The LADIS Study
Dement Geriatr Cogn Disord 2011, 32(4), , 279-286

Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to nonconverters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment