Jensen J;Langkilde AR;Fenst C;Nicolaisen MS;Roed HG;Christiansen M;Sellebjerg F
CD4 T cell activation and disease activity at onset of multiple sclerosis
J Neuroimmunol 2004, 149(1-2), , 202-209

We studied CD4 T cell activation in patients with clinically isolated syndromes (CIS) suggesting an initial attack of multiple sclerosis. The percentage of blood CD26+ CD4 T cells was increased in these patients, and correlated with magnetic resonance imaging disease activity and clinical disease severity. In contrast, the percentage of CD25+ CD4 T cells in cerebrospinal fluid correlated negatively with the cerebrospinal fluid concentration of myelin basic protein and the presence of IgG oligoclonal bands. These results suggest that distinct systemic and intrathecal T cell activation states correlate with disease activity and risk of subsequently developing MS in CIS patients