Samo Lasic
Research Interests
My main research involves advanced diffusion NMR/MRI methods for probing microstructural features of tissues, such as cell size, shape, organization, cell-membrane permeability and microcirculation. I’m particularly interested in non-invasive multidimensional diffusion encoding approaches, which allow teasing apart different tissue features and thus provide highly specific information useful in research and in clinical applications. Within the C-MORPH project at DRCMR, I’m focusing mainly on time-dependent diffusion effects in tensor-valued encoding and exploring possibilities of using these effects to access novel microstructural information
Research Groups
Curriculum Vitae
Education
2006
PhD in Physics, Faculty of Mathematics and Physics, University of Ljubljana, Slovenia
2001
MSc in Physics, Faculty of Mathematics and Physics, University of Ljubljana, Slovenia
Employments
2019 - Present
Senior Researcher, DRCMR
2018 - Present
Head of Technology Development at Random Walk Imaging
2016 - 2018
Chief scientific officer at Random Walk Imaging
2014 - 2016
Vinnova (Marie-Curie) fellow - visiting reasercher at the The Danish Research Centre for Magnetic Resonance (DRCMR)
2009 - 2016
Key Account Manager and Project Manager for OncoPulse at CR Development, NMR expert at CR Competence, AB
2007 - 2009
Postdoc at Physical Chemistry, Lund University, Sweden
2002 - 2007
Collaboration with science center Hiša Eksperimentov
2001 - 2007
Assistant professor for physics at Faculty for Mathematics and Physics, University of Ljubljana, Slovenia
2001 - 2007
Leading workshops within the program for high school in-service teachers training at Faculty for Mathematics and Physics, University of Ljubljana, Slovenia
2000 - 2001
Teaching physics at the Bežigrad high school, Ljubljana, Slovenia
Full CV
Publications
Lasič, S., Topgaard, D., Nilsson, M. & Lundell, H. A method of performing diffusion weighted magnetic resonance measurements on a sample.IPC nr. G01R33/56341, G01R33/4835, G01R33/543, G01R33/5608, A61B5/055, Patentnr. 16348580, 9 nov. 2017, Prioritetsdato 9 nov. 2016, Prioritetsnr. SE1651469-7 2019.
| WebSearch |
Lasič S, Szczepankiewicz F, Dall’Armellina E, Das A, Kelly C, Plein S, et al. Motion compensated b-tensor encoding for in vivo cardiac diffusion-weighted imaging. NMR Biomed 2019 ISSN 0952-3480 (In Press)
Brabec, S. Lasic, M. Nilsson, Time-dependent diffusion in undulating structures: Impact on axon diameter estimation, arXiv:1903.04536v1, NMR in Biomedicine, submitted
Lundell, M. Nilsson, T. Dyrby, G. Parker, P. H. Cristinacce, F. Zhou, D. Topgaard, S. Lasic Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail, Scientific Reports, accepted.
Ning L, Nilsson M, Lasič S, Westin CF, Rathi Y. Cumulant expansions for measuring water exchange using diffusion MRI. Chem. Phys. 2018; 148: 074109.
Lasič, S., H. Lundell, D. Topgaard, TB. Dyrby. Effects of imaging gradients in sequences with varying longitudinal storage time – Case of diffusion exchange imaging. Magn Reson Med. 2018, 79, 2228-2235.
Palmgren M, Hernebring M, Eriksson S, Elbing K, Geijer C, Lasič S, Dahl P, Hansen JS, Topgaard D, Lindkvist-Petersson K: Quantification of the Intracellular Life Time of Water Molecules to Measure Transport Rates of Human Aquaglyceroporins. J Membr Biol2017; 250:1–11.
Eriksson, K. Elbing, O. Söderman, K. Lindkvist-Petersson, D. Topgaard, S. Lasič. NMR quantification of diffusional exchange in cell suspensions with relaxation rate differences between intra and extracellular compartments. PLoS One. 12(5):e0177273 (2017).
Nilsson M, Lasič S, Drobnjak I, Topgaard D, Westin CF, Resolution limit of cylinder diameter estimation by diffusion MRI: The impact of gradient waveform and orientation dispersion, NMR Biomed., 2017, 30, (7), 1–13.
Ahlgren A, Knutsson L, Wirestam R, Nilsson M, Ståhlberg F, Topgaard D, Lasič S, Quantification of microcirculatory parameters by joint analysis of flow-compensated and non-flow-compensated intravoxel incoherent motion (IVIM) data, NMR Biomed., 2016, 29, (5), 640–649.
Lasič S, Oredsson S, Partridge SC, Saal LH, Topgaard D, Nilsson M, Bryskhe K, Apparent exchange rate for breast cancer characterization, NMR Biomed., 2016, 29, (5), 631–9.
Ristič T, Lasič S, Kosalec I, Bračič M, Fras-Zemljič L, The effect of chitosan nanoparticles onto Lactobacillus cells, React. Funct. Polym., 2015, 97, 56–62.
Eriksson S, Lasič S, Nilsson M, Westin C-F, Topgaard D, NMR diffusion-encoding with axial symmetry and variable anisotropy: Distinguishing between prolate and oblate microscopic diffusion tensors with unknown orientation distribution, J. Chem. Phys., 2015, 142, 104201.
Szczepankiewicz F, Lasič S, van Westen D, Sundgren PC, Englund E, Westin C-F, Ståhlberg F, Lätt J, Topgaard D, Nilsson M, Quantification of microscopic diffusion anisotropy disentangles effects of orientation dispersion from microstructure: applications in healthy volunteers and in brain tumors., Neuroimage, 2015, 104, 241–52.
Lasič S, Szczepankiewicz F, Eriksson S, Nilsson M, Topgaard D, Microanisotropy imaging: quantification of microscopic diffusion anisotropy and orientational order parameter by diffusion MRI with magic-angle spinning of the q-vector, Front. Phys., 2014, 2, (11), 1–14.
Eriksson S, Lasič S, Topgaard D, Isotropic diffusion weighting in PGSE NMR by magic-angle spinning of the q-vector., J. Magn. Reson., 2013, 226, 13–8.
Nilsson M, Lätt J, van Westen D, Brockstedt S, Lasič S, Ståhlberg F, Topgaard D, Noninvasive mapping of water diffusional exchange in the human brain using filter-exchange imaging., Magn. Reson. Med., 2013, 69, (6), 1572–80.
Lasič S, Nilsson M, Lätt J, Ståhlberg F, Topgaard D, Apparent exchange rate mapping with diffusion MRI, Magn. Reson. Med., 2011, 66, (2), 356–365.
Lasič S, Åslund I, Oppel C, Topgaard D, Söderman O, Gradzielski M, Investigations of vesicle gels by pulsed and modulated gradient NMR diffusion techniques, Soft Matter, 2011, 7, (8), 3947 – 3955.
Lasič S, Åslund I, Topgaard D, Magnetic Resonance Spectral Characterization of Diffusion with Chemical Shift Resolution, J. Magn. Reson., 2009, 199, (2), 166–172.
Stepišnik J, Lasič S, Mohorič A, Serša I, Sepe A, Velocity autocorrelation spectra of fluid in porous media measured by the CPMG sequence and constant magnetic field gradient., Magn. Reson. Imaging, 2007, 25, (4), 517–520.
Lasič S, Stepišnik J, Mohorič A, Serša I, Planinšič G, Autocorrelation spectra of an air-fluidized granular system measured by NMR, Europhys. Lett., 2006, 75, (6), 887–893.
Lasič S, Stepišnik J, Mohorič A, Displacement power spectrum measurement by CPMG in constant gradient., J. Magn. Reson., 2006, 182, (2), 208–214.
Stepišnik J, Lasič S, Mohorič A, Serša I, Sepe A, Spectral characterization of diffusion in porous media by the modulated gradient spin echo with CPMG sequence., J. Magn. Reson., 2006, 182, (2), 195–199.
Lasič S, Geyser model with real-time data collection, Eur. J. Phys., 2006, 27, (4), 995–1005.