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MR Methodology

The MR methodology group supports the research activities that involve magnetic resonance (MR) at the DRCMR.

MR is a cornerstone in the research at the department and is in many projects often used in conjunction with other independent methodologies. In this group, we support the MR acquisition part of these projects.

The centre has 7 MR scanners.  Four scanners used in both in research and in the clinic: two 3T Siemens Prisma and Verio and two 1.5T Siemens Espree and Avanto and two Philips Achieva systems (3T and 7T) dedicated to research only. We also have a preclinical Bruker BioSpec system (7T) used for animal research, post mortem imaging and method development on phantoms. In the MR Methodology group, we try to synchronize the data acquisition and quality, and try to maximize the potential of the different systems. 

Part of this work is to pioneer new techniques, exchange sequences between our own systems and with other sites around the world. An important aspect of this work is also to monitor data quality and to plan hardware repairs and updates. Work is also done on adopting cutting edge hardware built by our collaborators or in our own workshop. Furthermore, we organize the mandatory MR safety training for all staff at the DRCMR.

 

 

Selected Publications

Lundell H, Lasič S. 2020. Diffusion Encoding with General Gradient Waveforms. Topgaard D, editor. In Advanced Diffusion Encoding Methods in MRI. 24 ed. Royal Society of Chemistry. pp. 12-67. (New Developments in NMR). https://doi.org/10.1039/9781788019910-00012

Lundell H, Najac C, Bulk M, Kan HE, Webb AG, Ronen I. 2021. Compartmental diffusion and microstructural properties of human brain gray and white matter studied with double diffusion encoding magnetic resonance spectroscopy of metabolites and water. NeuroImage. 234:1-14. https://doi.org/10.1016/j.neuroimage.2021.117981

Henriques RN, Palombo M, Jespersen SN, Shemesh N, Lundell H, Ianuş A. 2021. Double diffusion encoding and applications for biomedical imaging. Journal of Neuroscience Methods. 348:Article 108989. https://doi.org/10.1016/j.jneumeth.2020.108989

Vincent O. Boer, Mads Andersen, Anna Lind, Nam Gyun Lee, Anouk Marsman & Esben T. Petersen
MR spectroscopy using static higher order shimming withMR spectroscopy using static higher order shimming withdynamic linear terms (HOS-DLT) for improved watersuppression, interleaved MRS-fMRI, and navigatorbasedmotion correction at 7T.
Magnetic Resonance in Medicine,  DOI: 10.1002/mrm.28202. 2020.

Lundell, H., Nilsson, M., Dyrby, T. B., Parker, G. J. M., Cristinacce, P. L. H., Zhou, F-L., Topgaard, D. & Lasič, S.
Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail.
Scientific Reports. 9, 1, p. 1-12, 9026. 2019.

Andersen, M., Björkman-Burtscher, I. M., Marsman, A., Petersen, E. T. & Boer, V. O.
Improvement in diagnostic quality of structural and angiographic MRI of the brain using motion correction with interleaved, volumetric navigators.
PLoS One. 14, 5, p. 1-16, e0217145. 2019.

Lundell, H. M. H., Ingo, C., Dyrby, T. B. & Ronen, I.
Accurate estimation of intra-axonal diffusivity and anisotropy of NAA in humans at 7T.
2017.

Lundell, H. M. H., Nilsson, M., Dyrby, T. B., Parker, G. J. M., Cristinacce, P. L. H., Zhou, F., Topgaard, D. & Lasic, S.
Microscopic anisotropy with spectrally modulated q-space trajectory encoding.
2017.

Group Members

Henrik Lundell

Group Leader

Lars G. Hanson

Show all group members (6)