Nathalie Just

Just N, Adriaensen H, Ella A, Chevillard PM, M, Batailler M, Dubois JP, Keller M, Migaud M. Blood oxygen level dependent fMRI and perfusion MRI in the sheep brain. Brain Research. 1760, 147360.2021

Just N, Functional Magnetic Resonance Spectroscopy in rodents. Accepted Special Issue in NMR in Biomedicine. NMR in Biomedicine, e4254 (In Press)

Just N, Segelcke D, Pogatzki-Zahn E, Faber C. Development of a stimulator for the characterization of mechanical-evoked pain-related supra-spinal processing using BOLD-fMRI in rodents. IEEE Transactions on Biomedical Engineering.2019 IEEE Transactions on Biomedical Engineering 67 (5), 1349-1356

Just N, Faber C.Probing activation-induced neurochemical changes using optogenetics combined with functional magnetic resonance spectroscopy: a feasibility study in the rat primary somatosensory cortex.J Neurochem. 2019 Aug;150(4):402-419. doi: 10.1111/jnc.14799.  Citations :6

van Alst TM, Wachsmuth L, Datunashvili M, Albers F, Just N, Budde T, Faber C.Anesthesia differentially modulates neuronal and vascular contributions to the BOLD signal.Neuroimage. 2019 Jul 15;195:89-103. doi: 10.1016/j.neuroimage.2019.03.057. Citations : 10

Sonnay S, Poirot J, N Just, Clerc AC, Gruetter R, Rainer G, Duarte J. Astrocytic and neuronal oxidative metabolism are coupled to the rate of glutamate–glutamine cycle in the tree shrew visual cortex. Glia 2018.  Citations : 28

Schelhaas S, Wachsmuth L, Hermann S, Rieder N, Heller A, Heinzmann K, Honess DJ, Smith DM, Fricke IB, Just N, Doblas S, Sinkus R, Döring C, Schäfers KP, Griffiths JR, Faber C, Schneider R, Aboagye EO, Jacobs AH. Thymidine Metabolism as Confounding Factor of 3'-Deoxy-3'-[18F] Fluorothymidine Uptake after Therapy in a Colorectal Cancer Model. Journal of Nuclear Medicine, 2018. Citations : 2

Sonnay S, Duarte JMN, Just N. Lactate and glutamate dynamics during prolonged stimulation of the rat barrel cortex suggest adaptation of cerebral glucose and oxygen metabolism. Neuroscience 2017;346, 337-348 Citations : 12

Just N, Sonnay S. Investigating the Role of Glutamate and GABA in the Modulation of Transthalamic Activity: A Combined fMRI-fMRS Study 2017;Frontiers in Physiology 8 Citations : 12-Book Chapter

Sonnay, S; Duarte, J; Just, N; Gruetter, R. Energy metabolism in the rat cortex under thiopental anaesthesia measured in vivo by ¹³C MRS. J of Neuroscience Research. 2017, 95 (11), 2297-2306 Citations : 6

Driencourt L, CJ Romero CJ, Lepore M, Eggenschwiler F, Reynaud O, Just N. T1 mapping of the mouse brain following fractionated manganese administration using MP2RAGE. Brain Structure and Function 222 (1), 201-214 Citations : 6

Amirmohseni S, Wachsmuth L, Just N, Faber C. Performance of MRS in metabolic profiling of the lumbar spinal cord in rat and mice. Magnetic Resonance Imaging 34 (8), 1155-1160 Citations : 2

Sonnay S, Duarte J, Just N, Gruetter R: Compartmentalised energy metabolism supporting glutamatergic neurotransmission in response to increased activity in the rat cerebral cortex: a 13C MRS study in vivo at 14.1 T 2016,, Journal of Cerebral Blood Flow & Metabolism 36 (5), 928-940 Citations : 36

Cordero MI, N Just, GL Poirier GL, Sandi C.Effects of paternal and peripubertal stress on aggression, anxiety, and metabolic alterations in the lateral septum.European Neuropsychopharmacology 2016; 26 (2), 357-367 Citations : 28

Sonnay S, Just N, Duarte JM, Gruetter R. Long stimulation paradigms for BOLD fMRI response study. NMR in Biomedicine- 2015; 414-421. Citations : 11

Sonnay S, Duarte JM,  Gruetter R, Just N. Measurement of long stimulation paradigms with BOLD fMRI in the rat brain for compartmentalized metabolism study. 2013;Journal of Neurochemistry 125, 279

Auffret M, Samim I, Lepore M, Gruetter R, Just N. Quantitative Activity Induced Manganese-dependent MRI for characterizing cortical layers in the primary somatosensory cortex of the rat. Brain structure and Function- 2016,Brain Structure and Function 221 (2), 695-707 Citations : 2 

Just N. Improving tumour heterogeneity MRI assessment with histograms. British Journal of Cancer. Minireview. September 2014. Br J Cancer 111, 2205-2213 Citations : 281

Just N., Xin L., Frenkel H., Gruetter R. Characterization of sustained BOLD activation in the rat barrel cortex and Neurochemical consequences. Neuroimage. 2013 Jul 1;74:343-51. Citations : 35 

Just N., Cudalbu C, Lei H, Gruetter R. Effect of manganese chloride on the neurochemical profile of the rat hypothalamus. J Cereb Blood Flow Metab. 2011;31(12):2324-33 Citations : 19

Just N, Gruetter R. Detection of neuronal activity and metabolism in a model of dehydration-induced anorexia in rats at 14.1T using manganese-enhanced MRI and proton MR spectroscopy. NMR in Biomed. 2011 Dec;24(10):1326-36 Citations : 14

Just N, Petersen C, Gruetter R. BOLD Responses to trigeminal nerve stimulation. Magn. Reson. Imaging. 2010, 28: 1143-1151. Citations : 20

Just N. Histogram analysis of the microvasculature of intracerebral human and murine glioma Xenografts. Magn. Reson. Med. 2011 Mar;65(3):778-89. Citations : 9 

Just N., Koh D-M, D’Arcy J, Collins DJ, Leach MO. Assessment of the effect of hematocrit-dependent arterial input functions on the accuracy of pharmacokinetic parameters in Dynamic ContrastEnhanced MRI NMR in Biomed, 2011 Aug;24(7):902-15. Citations : 20

Other publications and Reports:

X. Peña Piña, M Bach Cuadra, N.Kunz, N.Just, R. Gruetter and JP Thiran. Fast Bias Field Correction for 9.4T MRI, 2009, IEEE Medical Image Analysis. Citations : 3

W. van der Zwaag, J. P. Marques, H. Lei, N. Just, T. Kober and R. Gruetter. Minimization of Nyquist Ghosting for Echo-Planar Imaging at Ultra-High Fields Based on a "Negative Readout Gradient" Strategy", J.Magn. Reson. Imaging.2009. 30:1171-1178. Citations : 35

H. Lei, V. Mlynárik, N. Just, R. Gruetter. Snapshot gradient-recalled echo-planar images of rat brains at long echo time at 9.4 T. Magn Reson Imaging 2008, 6(7):954-960. Citations : 7

N. Just, N. Guilbaud, P. Genne, E Lancelot. Accepted Reports 050001 and 050002. Development of chemo-induced cancerous lymph nodes- Guerbet Part 1 and Part 2- January 2006

N. Just, N. Guilbaud, P. Genne, SE Alters.  Accepted Reports 050006. In-vivo study of AQ4N treatment  in Namalwa human lymphoma models.- Novacea -February 2006 

N. Just, N. Guilbaud, P. Genne, L.Levy- Accepted Report 040277- Biodistribution of Nanomag in the body of female C57BL/6 mice bearing subcutaneous C38 mouse colon tumors –Nanobiotix- 2006

N. Just, N Guilbaud, P Genne, D. Blanc. Accepted Report 040269. Antitumor activity study of WST09 in nude rats orthtopically xenografted with PC3-M human prostate tumours-NEGMA-LERADS- November 2005

N. Just, N. Guilbaud, P Genne, K Locke. Accepted Report- 050106. Determination of surrogate biomarkers of the vascular targeting agent MN029 in Nude rats bearing Calu-6 human Lung Tumours- Medicinova-November 2005

N. Just, N. Guilbaud, P. Genne, P Vrignaud Accepted Report 040106-Blood Oxygen Level Dependent (BOLD) MRI for evaluation of VTA in syngeneic DMBA chemo-induced tumor modelSanofi-Aventis- 2005  

N. Guilbaud, O. Duchamp, N. Just, Philippe Genne. Role of non invasive animal imaging in preclinical anticancer drug development.  Bull of Cancer 2005; 92(1):45-57 (All authors participated to the same extent N.Guilbaud and O Duchamp for animal models and N. Just for Imaging) Citations : 2

A. L Evelyn, D. Ila, R.L Zimmermann., N. Just: Ion beam modification of PES, PS and PVC Polymers in Nuclear Instruments and Methods in Physics Research B (1999),148,1141-1145. Citations : 31

Abstracts presented at International conference with peer review commitees

Just N, Faber C. Opto-functional Magnetic Resonance Spectroscopy: Investigating brain energetics under optogenetics and sensory stimulation. Joint ISMRM-ESMRMB meeting 2018, Paris, France

Just N, Wachsmuth L, Faber C. Is cerebral cortex metabolism upon optogenetic and sensory stimulation comparable? A comparative study using opto- and sensory H functional MRS. ESMRMB meeting 2017, Barcelona, SPAIN, oral

N Just, L Wachsmuth, C Faber. Feasibility of opto-magnetic resonance spectroscopy at 9.4 T. Journal of cerebral Blood Flow and Metabolism 37,pp486-487,2017

N Just, D Segelcke, C Faber, E Pogatzki-ZahnCerebral assessment of pharmacological modulation of spinal GABA (A) receptor using Functional BOLD MRI in a rat model of postoperative pain. Journal of cerebral Blood Flow and Metabolism 37,pp295-296,2017

S Sonnay, J Poirot, N Just, AC Clerc, R Gruetter, G Rainer, JMN Duarte. Rates oxidative metabolism in astrocytes and neurons are coupled to the glutamate-glutamine cycle in the tree shrew visual cortex .Journal Of Neurochemistry 142 (EPFL-CONF-230551), 148-148;2017

Sonnay, Sarah,  Just, N,  Gruetter, Rolf  Duarte, João. Energy Metabolism in the Rat CortexUnder Thiopental Anaesthesia Measured in Vivo by 13C MRS at 14.1T. 24th ISMRM Scientific Meeting, Singapore, 2016

Schmid, F,  Wachsmuth, L.,  Albers, F.,  Just, N  Schwalm, M., Stroh, A.,  Faber, Co. Light-Induced Activation of the Visual Network by Optogenetic FMRI (OfMRI) 24th ISMRM Scientific Meeting, Singapore, 2016

Just N, Gruetter R. High-Resolution T1 mapping of the mouse brain using MP2RAGE at 14.1T. 23^rd ISMRM Scientific Meeting, Toronto, Canada, 2015

Just N, Gruetter R. Temporal Analysis of barrel cortex metabolism during activation. ESMI 2015, Tubingen, Germany

Just N, Gruetter R. Evaluation of Mn²⁺ accumulation across cortical layers of the barrel cortex of rats. ESMI 2014. Antwerp, Belgium.

E. Vinckenbosch, N. Just. Sequence comparison and saturation pulse optimization for GlucoCEST at 14.1T, ESMI 2014, Antwerp, Belgium.

N.Just., R. Gruetter. "1H functional MRS of the rat barrel cortex and the thalamus during trigeminal nerve stimulation.  Preliminary investigation of the metabolic regulation of the barrel cortex by glutamatergic and GABAergic thalamocortical inputs. 22^nd ISMRM Scientific Meeting, Milan, Italy, 2014-Oral

Just N. Reynaud O. Gruetter R.  MP2RAGE in Mice. 22^nd ISMRM Scientific Meeting, Milan, Italy, 2014

Just.N. "Usefulness of histogram analysis for the investigation of tumour heterogeneity". 22nd ISMRM. Scientific Meeting, Milan, Italy, 2014 Educational session

Sonnay S, Duarte JM, Gruetter R. Just N. Long stimulation paradigms for BOLD fMRI response study. 22nd ISMRM Scientific Meeting, Milan, Italy, 2014  

N Just. M.Lepore , H.Frenkel, R.Gruetter . An improved activity-induced manganese-dependent MRI study of the rat barrel cortex.  21st ISMRM Scientific Meeting, Salt Lake City, United-States, 2013

N Just, R. Gruetter. Investigation of the metabolism of the rat barrel cortex during sustained BOLD fMRI. 2012 OHBM Annual Meeting in Beijing, China

N. Just, M Auffret, G. Poirier, M Cordero, R. Gruetter. Alteration of Metabolites in the lateral septum of peripubertally stressed rats. Accepted at 20th ISMRM Scientific Meeting, Melbourne, Australia, 2012.

N Just, R. Gruetter. Investigation of the BOLD contrast mechanisms initiated during prolonged trigeminal nerve stimulation. Accepted at 20th ISMRM Scientific Meeting, Melbourne, Australia, 2012.

20.N Just, R. Gruetter. Measurement of Metabolite concentration changes in the rat barrel cortex during sustained trigeminal stimulation. Accepted at 20th ISMRM Scientific Meeting, Melbourne, Australia, 2012. Oral presentation.

Poirier GL, Skachokova Z, Peich MC, Just N, Cordero MI, Sandi C.Peripubertal stress yields reduced adult lateral septum GABA and a cue interpretation bias that may be pharmacologically alleviated in rats. EBBS-Seville 2011

N Just, R. Gruetter. Investigation of hypothalamic neuronal and metabolic mechanisms of anorexia with Manganese-enhanced MRI and Proton MR Spectroscopy-2399- 19th ISMRM Scientific Meeting, Montreal, Canada, 2011.

N Just, R. Gruetter. Effect of Manganese chloride on the neurochemical profile of the rat hypothalamus-2398- 19th ISMRM Scientific Meeting, Montreal, Canada, 2011.

24.N Just, C. Petersen, R. Gruetter. BOLD fMRI of the mouse barrel cortex-1579- 19th ISMRM Scientific Meeting, Montreal, Canada, 2011.

N Just, R. Gruetter. Functional Magnetic Resonance Spectroscopy of the rat barrel cortex-1590-19th ISMRM Scientific Meeting, Montreal, Canada, 2011.

N Just, R. Gruetter. An investigation of the metabolism of the rat barrel cortex during sustained trigeminal nerve stimulation- XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function and the Xth International Conference on Quantification of Brain Function with PET Barcelona, Spain, May 25 - 28, 2011

N. Just, M.Baud, JM Petit, P.Magistretti, R.Gruetter. Brain neurochemical effects of long-term sleep fragmentation investigated in mice at 14.1T using 1H-MRS. 18th ISMRM Scientific Meeting, Stockholm, Sweden, 2010.

M. Baud, N. Just, R.Gruetter, JM Petit, P.Magistretti, JM Petit. Effects of long-term sleep fragmentation on the EEG and brain energy metabolism. 7th  FENS Forum of European Neuroscience, Amsterdam, The Netherlands., 2010.

N. Just, MI Cordero Campana, G. Poirier, H. Lei, C. Sandi, R. Gruetter. Neurochemical profile of the rat lateral septum investigated with 1H-MRS. 18th ISMRM Scientific Meeting, Stockholm, Sweden, 2010.

N. Just, H. Frenkel, S.Germain, R.Gruetter. BOLD response and associated metabolic changes in the rta barrel cortex following sustatined trigeminal nerve stimulation. 18th ISMRM Scientific Meeting, Stockholm, Sweden, 1199 2010.

N.Just, S Germain, M Lauritzen, R.Gruetter Assessment of rat barrel cortex BOLD responses to trigeminal nerve stimulation: On the linearity of BOLD fmRI changes against neuronal activity in the barrel cortex 17th ISMRM Scientific Meeting, Honolulu, Hawaï, 1603, 2009. In competition for poster award.

N. Just, R. Gruetter. Manganese enhanced MRI and 1H MR spectroscopy of the hypothalamus in a model of dehydration induced anorexic rats. 17th ISMRM Scientific Meeting, Honolulu, Hawaï, 156, 2009. Oral presentation

N. Just, H. Frenkel, S.Germain, R.Gruetter, “BOLD fMRI investigation of the trigeminal nerve stimulation at 9.4T”. 16th ISMRM Scientific Meeting, Toronto, Canada, p. 2436, 2008

N. Just, H. Frenkel, S.Germain, R.Gruetter, “Activation of the whisker barrel in rat brain localized by fMRI”. USGEB 2008, 162

X. Peña Piña, M Bach Cuadra, N.Kunz, N.Just, R. Gruetter and JP Thiran, “Fast Bias Field Correction for 9.4T MRI”, EDAS 2008

N.Just, N.Kunz, R.Charrier, HX Lei, M.Bach Cuadra, R.Gruetter, JP Thiran, “Bias Field Correction of surface coil MR images of rodent brain acquired at high field’’ in Proc. ISMRM Fifteenth Scientific Meeting, Berlin, Germany,p.3713, 2007.

N.Just, N.Kunz, I.Kohler, P.Huppi, S.Sizonenko and R.Gruetter, “Investigation of metabolite changes in neonatal rat brain after cerebral hypoxia-ischemia using 1H-spectroscopy at 9.4” in Proc. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, p.2379, 2007

W. van der Zwaag, H. Lei, N. Just, J. Marques and R. Gruetter. Minimization of Nyquist ghosting for fMRI at ultra-high fields based on a ‘negative read-out gradient’ strategy. Proc. Intl. Soc. Mag. Reson. Med., 17 (2008), Toronto.

D.Blanc, H Ficheux, N.Just, N. Guilbaud. Proc of AACR 2006 meeting Photodynamic therapy with TOOKAD in an orthotopic human prostate cancer xenografted in nude rats

N Just, N Guilbaud, Ph Genne and K Locke. Proc of AACR 2006 meeting and 14th ISMRM Scientific Meeting, Seattle, USA. Assessment of the anti-vascular activity of MN-029 in Calu-6 human lung tumors using DCE-MRI and FLOOD MRI.

N. Just,  B. van der Sanden, O. Duchamp, H Lahrech, L. Lamalle, N. Guilbaud, P Genne, C Remy. Proc Int Soc.Magn Reson Med, 2005. Vessel Size, Blood Volume and Diffusion MR imaging of different glioma models in rats

NT Taguchi, E.T Miura F. Bichat, N.Just, O Duchamp, P Walker, N. Guilbaud, T Isoe. Proc Am Assoc Cancer Res. AACR 2005. The VEGF receptor inhibitor KRN951 decreases vascular permeability in tumors and inhibits tumor growth: an analysis using dynamic contrast enhanced magnetic resonance imaging.

N. Just, O.Duchamp, B van der Sanden, H. Lahrech, N.Guilbaud, P.Genne, C.Rèmy and C. Segebarth. Proc Am Assoc Cancer Res. AACR 2005. Evaluation of the BCNU chemosensitivity of a panel of glioma models in rats in relation with vessel size index, blood volume and diffusion MR imaging parameters

B van der Sanden, O. Duchamp, L. Lamalle, R Farion,  Z.Housni, Guilbaud N,  N Just, P Genne, C. Rémy. Proc  Am Assoc Cancer Res  2004- Abstract-MRI of blood volume and vessel size in rat glioma models. The impact of the tumor blood volume status on BCNU treatment.

O.Duchamp, Walker P, Bataille A, Genne P, Brunotte, F, Bichat F, Just N, Guilbaud N. Proc  Am Assoc Cancer Res- AACR  2004- Abstract    and   Eurocancer/SFC conference Paris 2004  Abstract 162 -DCE-MRI assessment of responses to hormonotherapy in preclinical breast and  prostate cancer models in rats

N. Just, C.Hayes, I.J Rowlands and M.O Leach. Determination of Plasma Gd-DTPA concentration from DCE-MR images. In Proc 6th British Chapter meeting of the ISMRM-Liverpool- June2000Awarded Stipend

N. Just, C. Hayes, S. Eccles and M.O. Leach-Assessment of tumour response to MMPI treatment using dynamic contrast-enhanced MR images.2001 National CRC cancer Symposium- 11-14 February 2001

N. Just, C. Hayes, S. Eccles and M.O. Leach. Assessment of tumour response to MMPI treatment using dynamic contrast-enhanced MR images. ISMRM-ESMRMB Joint Annual Meeting, Glasgow, Scotland, UK, April 2001

N. Just, JA D'Arcy, D.J. Collins and M.O. Leach In-vivo measurement of the Arterial Input function using a T2*-weighted image acquired with a Dual Gradient Echo sequence. 10th ISMRM Scientific Meeting, Honolulu, Hawai, 2002-Awarded Stipend.

N.Just and Martin O. Leach. Assessment of the Gd relaxivity dependence on Haematocrit and oxygenation by Modelling  Susceptibility Changes and  R₂* changes in blood. ESMRMB 2002, Cannes.

N Just, D Koh, D.J Collins and M.O.Leach. Gd-DTPA Calibration curves in human blood as a function of haematocrit for the quantification of the arterial Input function in Femoral arteries- (Oral presentation) ISMRM 2003. Awarded Stipend.

N Just, A.S Dzik-Jurasz, Chris Parker, D. Collins and M.O.Leach. The influence of a measured AIF corrected for haematocrit  on the calculated vascular parameters of a 2-compartment model in prostate cancer- ISMRM 2003

N Just, AS Dzik-Jurasz, C. Parker, S. Walker, D. Collins and M.O.Leach (Oral Presentation) .The influence of a measured AIF corrected for haematocrit on the calculated vascular parameters of pharmacokinetic models in prostate cancer. Annual NMR Symposium, Manchester University, January 2003

M.O Leach, N.Just, S. Walker, A. Degenhard, M. White, J.D'Arcy and D.J.Collins. Measuring and Analysing vascular properties using Magnetic Resonance Imaging. Abstract presented to the World Conf in Medicine and Physics 2003.