Tim Dyrby

Email

Tel.

+45 3862 6542

Position

Associate Professor

Affiliations

Image Analysis and Computer Graphics section, DTU Compute

Research Interests

My main interest is microstructure plasticity imaging in normal and diseased conditions. How to non-invasively map microstructural features of brain tissue i.e. to statistically model measures of axon diameter and density, as well as general anisotropic measures. To understand the architecture of the microstructural environment and its connectivity that impact microstructural imaging and modeling. Key imaging technology is diffusion MRI where we design and combine acquisitions to reflect specific microstructural features. Diffusion MRI is translational so I work with powerful preclinical MRI scanners to develop, test and validate new diffusion MRI acquisitions and apply them to human patient studies.

Research Groups

Coordinator of the resarch area MR Physics and Analyses
Microstructure and Plasticity (Group Leader)
Preclinical (Group Leader)
Traumatic Brain Injury
Multiple Sclerosis

Curriculum Vitae

Education

2008

PhD: DTU informatics, Technical Uni. Denmark (DTU), DK

2002

MSc: DTU informatics, Technical Uni. Denmark (DTU), DK

1997

BSc.E.E: Dep. of Electronic, Engineering College of Copenhagen, DK

1992

Elektroniktekniker, Frederiksberg Tekniske Skole, DK

Employments

2015 - Present

Associate Professor in multi-modal imaging, Image Analysis and Computer Graphics section, DTU compute

2014 - Present

Head of Preclinical research, DRCMR , Cph. Uni. Hosp.,Hvidovre, DK

2010 - Present

Senior Researcher, DRCMR, Cph. Uni. Hosp.,Hvidovre, DK

2009 - Present

Group leader of the Diffusion Imaging Group (DIG), DRCMR, Cph. Uni. Hosp.,Hvidovre, DK

2009 - 2010

Postdoc, DRCMR, Cph. Uni. Hosp.,Hvidovre, DK

Publications

Large I, Bridge H, Ahmed B, Clare S, Kolasinski J, Lam WW, Miller KL, Dyrby TB, Parker AJ, Smith JET, Daubney G, Sallet J Bell AH, Krug K, Individual differences in the alignment of structural and functional markers of the V5/MT complex in primates, Cerebral Cortex, 2016, Accepted

Donahue C, Sotiropoulos S, Jbabdi S, Hernandez-Fernandez M, Beherens T, Dyrby TB, Kennedy H, Knoblauch K, Coalson T, Glasser M, Van Essen D, Using Diffusion Tractography to Predict Cortical Connection Strength and Distance: A Quantitative Comparison with Tracers in the Monkey, Journal Neuroscience, 2016, Accepcted 

Innocenti GM, Dyrby TB, Winther-Andersen K , Rouillier EM, Caminiti R, The crossed projection to the striatum in two species of monkey and in humans: Behavioral and evolutionary significance, Cerebral Cortex accepted

Reislev NL, Dyrby TB, Siebner HR, Kupers R, Simultaneous assessment of white matter changes in microstructure and connectedness in the blind brain, Neural Plasticity, Article ID 795865, 2015

Ratzer R, Iversen P, Börnsen L, Dyrby TB, Christensen JR, Ammitzbøll C, Madsen CG, Garde E, Andersen B, Hyldstrup L, Sørensen PS, Siebner HR, Sellebjerg F, Monthly oral methylprednisolone pulse treatment in progressive multiple sclerosis, Multiple Sclerosis Journal, (Accepted)

Shemesh N, Jespersen SN, Alexander DC, Cohen Y, Drobnjak I, Dyrby TB, Finsterbusch J, Koch MA, Kuder T, Laun F, Lawrenz M, Lundell H, Mitra PP, Nilsson M, Özarslan E, Topgaard D, Westin CF, CONVENTIONS AND NOMENCLATURE FOR DOUBLE DIFFUSION ENCODING (DDE) NMR AND MRI, Magn Reson Med, 2015 (accepted)

Knösche TR, Anwander A, Liptrot MG, Dyrby TB, Validation of Tractography – Comparison with Manganese Tracing, Human Brain Mapping (Accepted), 2015

Reislev NL, Kupers R, Siebner HR, Ptito M, Dyrby TB, Blindness alters the microstructure of the ventral but not the dorsal visual stream. Brain Structure and Function, (Accepted), 2015

Sickmann HM, Arentzen TS, Dyrby TB, Plath N, Kristensen MP, Prenatal Stress Produces Sex Specific Changes in Depression-like Behavior in Rats: Implications for increased vulnerability in females. Journal of Developmental Origins of Health and Disease, 2015, 6:462-74.

Daducci A, Canales-Rodriguez EJ, Zhang H, Dyrby TB, Alexander DC, Thiran JP, Accelerated Microstructure Imaging via Convex Optimization (AMICO) from diffusion MRI data, Neuroimage, 35, 32-44, 2015

Lundell HM, Sønderby CK, Dyrby TB, Diffusion weighted imaging with circularly polarized oscillating gradients, Magn Reson Med., 73(3), 171:1176, 2015

Dyrby TB, Lundell H, Burke MW, Reislev NL, Paulson OB, Ptito M, Siebner HR, Interpolation of diffusion weighted imaging datasets, NeuroImage,103, 202-213, 2014

Jespersen SN, Lundel H, Sønderby C, Dyrby TB, Commentary on ”Microanisotropy imaging: quantification of microscopic diffusion anisotropy and orientation of order parameter by diffusion MRI with magic-angle spinning of the q-vector”, Frontiers in Physics, doi: 10.3389/fphy.2014.00028, 2014

Lundell HM, Alexander DC, Dyrby TB, High angular resolution diffusion imaging with stimulated echoes: compensation and correction in experiment design and analysis, NMR in Biomedicine, 27 (8), 918-925, 2014

Liptrot MG, Sidaros K, Dyrby TB, Addressing The Path-Length-Dependency Confound In White Matter Tract Segmentation, PlosOne, 9 (5), e96247, 2014

Lyksborg M, Siebner HR, Sørensen PS, Blinkenberg M, Parker GJM, Dogonowski A, Garde E, Larsen R, Dyrby TB, Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity, PlosOne, 9 (4), e95540, 2014

Christensen JR, Ratzer R, Börnsen L, Lyksborg M, Garde E, Dyrby TB, Siebner HR, Sørensen PS, Sellebjerg F, Natalizumab in progressive MS – results of an open-label phase 2A proof-of- concept trial. Neurology, 2014 

Sønderby CK, Lundell HM, Søgaard LV, Dyrby TB, Apparent exchange rate imaging in anisotropic systems, Magn Reson Med., 72 (3), 756:762, 2014

Jespersen SN, Lundell H, Sønderby KS, Dyrby TB, Rotationally invariant sampling of double pulsed field gradient diffusion: estimating apparent compartment eccentricity, NMR in biomedicine, 2013

Assaf Y, Alexander DC, Jones DK, Bizzi A, Behrens T, Clark C, Cohen Y, Dyrby TB, Huppi P, Knoesche T, LeBihan D, Parker GJM, CONNECT Consortium, The CONNECT project: Combining Macro- and Micro-structure, NeuroImage, 2013

Dogonowski AM, Siebner HR, Sørensen PS, Paulson OB, Dyrby TB, Blinkenberg M, Madsen KH, Resting-state connectivity of premotor cortex reflects disability in multiple sclerosis, Acta Neurologica Scandinavica, , 2013 

Dogonowski A, Siebner HR, Sørensen PS, Wu X, Biswal B, Paulson OB, Dyrby TB, Skimminge A, Blinkenberg M, Madsen KH, Expanded functional coupling of subcortical nuclei with the motor resting-state network in multiple sclerosis, Multiple Sclerosis Journal, 19: 559-566, 2013

Dyrby TB, Søgaard LV, Hall MG, Ptito M, Alexander DC, Contrast and stability of the axon diameter index from microstructure imaging with diffusion MRI, Magn Reson Med., 70(3), 711:721, 2013

Lundell H, Barthelemy D, Biering-Sørensen F, Cohen-Adad J, Nielsen JB, Dyrby TB, Fast diffusion tensor imaging and tractography of the whole cervical spinal cord using point spread function corrected echo planar imaging., Magn Reson Med. 69(1):144-9. 2013

Lundell H, Nilsen JB, Ptito M, Dyrby TB, Distribution of collateral fibers in the monkey cervical spinal cord detected with diffusion weighted magnetic resonance imaging, Neuroimage, 2011, 1;56(3):923-9.

Dyrby TB, Baaré WF, Alexander DC, Jelsing J, Garde E, Søgaard LV, An ex vivo imaging pipeline for producing high-quality and high-resolution diffusion weighted imaging datasets, Hum Brain Mapp. 2011;32(4):544-63

Lundell H, Barthelemy D, Skimminge A, Dyrby TB, Biering-Sørensen F, Nielsen JB. Independent spinal cord atrophy measures correlate to motor and sensory deficits in individuals with spinal cord injury. Spinal Cord. 2010

Alexander DC, Hubbard PL, Hall MG, Moore EA, Ptito M, Parker GJ, Dyrby TB. Orientationally invariant indices of axon diameter and density from diffusion MRI Neuroimage. 2010 :1374-89

Dyrby TB, Rostrup E, Baaré WF, van Straaten EC, Barkhof F, Vrenken H, Ropele S, Schmidt R, Erkinjuntti T, Wahlund LO, Pantoni L, Inzitari D, Paulson OB, Hansen LK, Waldemar G; LADIS study group. Segmentation of age-related white matter changes in a clinical multi-center study. Neuroimage, Vol 41, pp. 335-45, 2008 

Dyrby TB, Sogaard LV, Parker GJ, Alexander DC, Lind NM, Baare WF, Hay-Schmidt A, Eriksen N, Pakkenberg B, Paulson OB, Jelsing J., Validation of in vitro probabilistic tractography. Neuroimage, Vol 37, pp. 1267-1277. 2007

Haugbol S, Pinborg LH, Arfan HM, Frokjaer VM, Madsen J, Dyrby TB, Svarer C, Knudsen GM. Reproducibility of 5-HT2A receptor measurements and sample size estimations with [18F]altanserin PET using a bolus/infusion approach. Eur J Nucl Med Mol Imaging, Vol 34, pp. 910-5, 2007

Jelsing J, Hay-Schmidt A, Dyrby T, Hemmingsen R, Uylings HB, Pakkenberg B. The prefrontal cortex in the Gottingen minipig brain defined by neural projection criteria and cytoarchitecture. Brain Res Bull, Vol 70, pp. 322-36, 2006