Kathrine Skak Madsen



+45 3862 3323


Senior Researcher

Research Interests

My research is focused on individual differences in human brain and behavioural development, and on how environmental (e.g. stress, physical activity, alcohol use), genetic and hormonal (e.g. cortisol, sex hormones) factors modulate such development. I study this by employing multimodal neuroimaging techniques, behavioural and clinical assessments, and hormonal sampling. During my PhD and postdoc studies I collected comprehensive longitudinal MRI and behavioural data (up to 11 assessments) with 6 months interval in a cohort of typically-developing children aged 7-19 years. My work has primarily focused on the relationship between brain structure and performance on different behavioural functions.

Research Groups

Brian Maturation Group (Group Leader)

Curriculum Vitae



Higher Educational Teaching, University of Copenhagen, Denmark


PhD in Neuroscience, DRCMR & Cimbi, Faculty of Health Sciences, University of Copenhagen, Denmark


MSc in (Neuro)biology, University of Copenhagen, Denmark


2015 - Present

Senior Researcher, DRCMR

2015 - 2015

Senior Researcher, Cimbi

2011 - 2015

Cimbi work package leader: Brain maturation, DRCMR & Cimbi

2011 - 2014

Postdoc, DRCMR & Cimbi

2008 - 2011

PhD Student, DRCMR & Cimbi

2006 - 2008

Research Assistant, DRCMR & Cimbi

2004 - 2006

Research Volunteer and member of the Unit of Cognitive Neuroscience, Department of Psychology, University of Copenhagen


Madsen KS. Evaluation of continuous formative assessment during lectures. In Improving University Science Teaching and Learning: Pedagogical Projects 2015, vol 8, no. 1-2, chap. 22, pp. 261-274.

Angstman S, Madsen KS, Skimminge A, Jernigan TL, Baaré WF, Siebner HR. Microstructural asymmetry of the corticospinal tracts predict right-left differences in circle drawing skill in right-handed adolescents. Brain Structure and Function, 2016, Epub ahead of print. 

Knudsen GM, Jensen PS, Erritzoe D, Baaré WF, Ettrup A, Fisher PM, Gillings N, Hansen HD, Hansen LK, Hasselbalch SG, Henningson S, Herth MM, Holst KK, Iversen P, Kessing LV, Macoveanu J, Madsen KS, Mortensen EL, Nielsen FÅ, Paulson OB, Siebner HR, Stenbæk DS, Svarer C, Jernigan TL, Strother SC, Frokjaer VG. The Center for Integrated Molecular Brain Imaging (Cimbi) Database. Neuroimage, 2016, 124(Pt B): 1213-19.

Holm SK, Vestergaard M, Madsen KS, Baaré WF, Hammer TB, Born AP, Siebner HR, Paulson OB, Uldall PV. Children and adolescents previously treated with glucocorticoids display lower verbal intellectual abilities. Acta Paediatrica, 2015, 104(8): 784-91.

Frokjaer VG, Erritzoe D, Holst KK, Madsen KS, Fisher PM, Madsen J, Svarer C, Knudsen GM. In abstinent MDMA users the cortisol awakening response is off-set bur associated with prefrontal serotonin transporter binding as in non-users. International Journal of Neuropsychopharmacology, 2014, 17(8): 1119-28.

Aarnink SH, Vos SB, Leemans A, Jernigan TL, Madsen KS, Baaré WFC. Automated Longitudinal Intra-Subject Analysis (ALISA) for diffusion MRI tractography. Neuroimage, 2014, 86:404-416.

Klarborg B*; Madsen KS*; Vestergaard M; Skimminge A; Jernigan TL; Baaré WFC. Sustained attention is associated with right superior longitudinal fasciculus and superior parietal white matter microstructure in children. Human Brain Mapping, 2013, 34(12): 3216-32.

Barüel Johansen L; Siebner HR; Werge T; Madsen KS. Hjernen - genetik og udvikling i billeder. In Hjerneforum's book: Den genetiske hjerne. Tommerup N. (Ed.) 2013, chap. 4, pp. 23-6.

Frokjaer VG; Erritzoe; Holst KK; Jensen PS; Rasmussen PM; Fisher PM; Baaré W; Madsen KS; Madsen J; Svarer C; Knudsen GM. Prefrontal serotonin transporter availability is positively associated with the cortisol awakening response. European Neuropsychopharmacology, 2013, 23(4): 285-94.

Madsen KS; Jernigan TL; Iversen P; Frokjaer VG; Knudsen GM; Siebner HR; Baare WF. Hypothalamic-pituitary-adrenal axis tonus is associated with hippocampal microstructural asymmetry. Neuroimage, 2012, 63(1): 95-103.

Madsen KS; Jernigan TL; Iversen P; Frokjaer VG; Mortensen EL; Knudsen GM; Baare WF. Cortisol awakening response and negative emotionality linked to asymmetry in major limbic fibre bundle architecture. Psychiatry Research: Neuroimaging, 2012, 201(1): 63-72.

Madsen KS; Baaré WF; Skimminge A; Vestergaard M; Siebner HR; Jernigan TL. Brain microstructural correlates of visuospatial choice reaction time in children. Neuroimage, 2011, 58(4): 1090-1100.

Jernigan TL; Baare WF; Stiles J; Madsen KS. Postnatal brain development: Structural imaging of dynamic neurodevelopmental processes. Progress in Brain Research 2011, 189: 77-92.

Vestergaard M*; Madsen KS*; Baare WF; Skimminge A; Ejersbo LR; Ramsoy TZ; Gerlach C; Akeson P; Paulson OB; Jernigan TL. White matter microstructure in superior longitudinal fasciculus associated with spatial working memory performance in children. Journal of Cognitive Neuroscience, 2011, 23(9): 2135-2146.

Madsen KS; Baare WF; Vestergaard M; Skimminge A; Ejersbo LR; Ramsoy TZ; Gerlach C; Akeson P; Paulson OB; Jernigan TL. Response inhibition is associated with white matter microstructure in children. Neuropsychologia, 2010, 48(4): 854-862.

Madsen KS; Holm DA; Sogaard LV; Rowland IJ. Effect of paramagnetic manganese cations on (1)H MRS of the brain. NMR in Biomedicine, 2008, 21(10): 1087-1093.

Mala H; Alsina CG; Madsen KS; Sibbesen EC; Stick H; Mogensen J. Erythropoietin improves place learning in an 8-arm radial maze in fimbria-fornix transected rats. Neural Plasticity, 2005, 12: 329-340.