Lars G. Hanson

Email

Tel.

+45 3862 2977

Position

MSc PhD, Senior scientist

Research Interests

Research topics: Medical Magnetic Resonance Imaging (MRI) techniques and applications. Sequence development, spectroscopy, functional og dynamic measurements, visualization and MR physics.

Overview: The research focus is MRI methodology and technology in a broad sense. This includes imaging and spectroscopy methodology, mostly of general nature or for brain. The developed techniques were used in studies of multiple sclerosis, depression, MLD, and muscle energetics, for example. Recent research includes hyperpolarized imaging, fast spectroscopic imaging, motion correction, and encoding of non-MR signals in MRI, e.g. for artifact correction. Interests also include MR fundamentals, and development of widely used educational material and software made freely available via the DRCMR homepage.

Affiliations: Senior Scientist and group leader at the DRCMR (http://www.drcmr.dk/acquisition). Also Associate Professor at the DTU Center for Magnetic Resonance (http://www.cmr.elektro.dtu.dk) and active in the Center for Hyperpolarization in Magnetic Resonance (http://www.hypermag.elektro.dtu.dk).

Teaching: Teaches MRI understanding at DRCMR (http://www.drcmr.dk/mri-course) for a broad audience, and various technical MRI courses at DTU (see list via links above).

Research Groups

Acquisition Technology (Group leader)
Ultra-High Field MR

Curriculum Vitae

Education

1999

Ph.D., University of Copenhagen, Denmark

1995

M.Sc. Physics, University of Copenhagen, Denmark

Employments

2009 -

Associate Professor, Technical University of Denmark

1999 -

Senior Researcher, DRCMR

1996 - 1999

Introductory and Ph.D Stipend, DRCMR

1995 - 1996

Promotion Stipend, Max Planck Institute for Quantum Optics, Germany

Full CV

Publications

Göksu C, Scheffler K, Ehses P, Hanson L.G, Thielscher A. Sensitivity Analysis of Magnetic Field Measurements for Magnetic Resonance Electrical Impedance Tomography (MREIT), Magn Reson Med, in press.

Pedersen J.O., Hanson C.G., Xue R. & Hanson L.G., Encoding of Inductively Measured k-Space Trajectories in MR Raw Data. Proc. of the 25th annual meeting of the ISMRM, 3906, 2017

Pedersen J.O., Hanson C.G., Xue R. & Hanson L.G., Mary had a little Lamb: Scanner-recorded speech during MRI without gradient-induced sound. Oral pitch, Proc. of the 25th annual meeting of the ISMRM, 765, 2017

Magnusson  P.O., Boer V.O., Marsman A., Hanson L.G. & Petersen E.T., GABA-edited echo-planar spectroscopic imaging (EPSI) with MEGA-sLASER at 7T. Oral presentation, Proc. of the 25th annual meeting of the ISMRM, 1255, 2017

Eldirdiri A., Posse S., Hanson L.G, Hansen R.B., Hansen A.E. & Ardenkjær-Larsen J.H.,  Echo Planar Spectroscopic Imaging of Hyperpolarized 13C in a Clinical System with Reduced Chemical Shift Artifacts. Proc. of the 25th annual meeting of the ISMRM, 3691, 2017 

Göksu C., Hanson L.G., Ehses P., Scheffler K. & Thielscher A., Human In-vivo MR Current Density Imaging (MRCDI) Based on Optimized Multi-echo Spin Echo (MESE). Proc. of the 25th annual meeting of the ISMRM, 4039, 2017 

Hansen R.B., Mariager C.Ø., Laustsen C., Schulte R.F., Ardenkjær-Larsen J.A. & Hanson L.G., Improved reconstruction for IDEAL spiral CSI. Proc. of the 25th annual meeting of the ISMRM, 3041, 2017

Hanson L.G., Day 1 of MRI and NMR education: Interactive visualization of MR basics. Proc. of the 25th annual meeting of the ISMRM, 3818, 2017

Møller-Bisgaard, S., Ejbjerg, B. J., Eshed, I., Hørslev-Petersen, K., Hetland, M. L., Jurik, A. G., Thomsen, H., Torfing, T., Stengaard-Pedersen, K., Junker, P., Krogh, N. S., Lottenburger, T., Ellingsen, T., Andersen, L. S., Skjødt, H., Svendsen, A. J., Tarp, U., Hansen, I. T., Pødenphanth, J., Pedersen, J. K., Lindegaard, H., Hanson, L. G., Vestergaard, A., Glinatsi, D. & Østergaard, M. Effect of a treat-to-target cyclosporin on MRI-assessed synovitis, osteitis, tenosynovitis, bone erosion, and joint space narrowing in early rheumatoid arthritis: results from a 2-year randomized double-blind. Scandinavian Journal of Rheumatology. In press. WebSearch

Andersen, M., Hanson L. G., Madsen, K. H., Wezel, J., Boer, V., van der Velden, T., van Osch, M. J. P., Klomp, D., Webb, A. G. & Versluis, M. J. Measuring motion-induced B0-fluctuations in the brain using field probes. Magnetic Resonance in Medicine, 75(5):2020-30, 2016. WebSearch

Herskind, A., Ritterband-Rosenbaum, A., Willerslev-Olsen, M., Lorentzen, J., Hanson, L., Lichtwark, G. & Nielsen, J. B. Muscle growth is reduced in 15-month-old children with cerebral palsy. Developmental Medicine and Child Neurology, 58(5):485-91, 2016. WebSearch

Jørgensen, A., Magnusson, P., Hanson, L. G., Kirkegaard, T., Benveniste, H., Lee, H., Svarer, C., Mikkelsen, J. D., Fink-Jensen, A., Knudsen, G. M., Paulson, O. B., Bolwig, T. G. & Jorgensen, M. B. Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression. Acta Psychiatrica Scandinavica. 133, p. 154-164, 2016. WebSearch

Hanson, L.G. The ups and downs of NMR described by classical and quantum mechanics. Book chapter in "Anthropic Awareness - The Human Aspects of Scientific Thinking in NMR Spectroscopy and Mass Spectrometry", 32 pages, edited by C  Szantay, Jr., Elsevier, 2015. WebSearch

Hastrup, N., Khalilieh, S., Dale, D. C., Hanson, L. G., Magnusson, P., Tzontcheva, A., Tseng, J., Huyck, S., Rosenberg, E. & Krogsgaard, K. The effects of the CXCR2 antagonist, MK-7123, on bone marrow functions in healthy subjects. Cytokine. 72, 2, p. 197-203, 2015. WebSearch

Wu, X., Hanson, L. G., Skimminge, A., Sorensen, P. S., Paulson, O. B., Mathiesen, H. K. & Blinkenberg, M. Cortical N-acetyl aspartate is a predictor of long-term clinical disability in multiple sclerosis. Neurological Research. 36, 8, p. 701-08, 2014. WebSearch

Lund, H., Krakauer, M., Skimminge, A., Sellebjerg, F., Garde, E., Siebner, H. R., Paulson, O. B., Hesse, D. & Hanson, L. G. Blood-brain barrier permeability of normal appearing white matter in relapsing-remitting multiple sclerosis. P L o S One. 8, 2, s. e56375 2013. WebSearch

Axelsen, M. B., Poggenborg, R. P., Stoltenberg, M., Kubassova, O., Boesen, M., Hørslev-Petersen, K., Bliddal, H., Hanson, L. G. & Østergaard, M. Reliability and responsiveness of dynamic contrast-enhanced magnetic resonance imaging in rheumatoid arthritis. Scandinavian Journal of Rheumatology. 42, 2, p. 115-22, 2013. WebSearch

Blinkenberg M;Mathiesen HK;Tscherning T;Jonsson A;Svarer C;Holm S;Sellebjerg F;Paulson OB;Hanson LG;Sorensen PS. Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: An exploratory study. Neurol Res 2012, 34(1), 52-58. WebSearch

Axelsen M;Stoltenberg M;Poggenborg R;Kubassova O;Boesen M;Bliddal H;Horslev-Petersen K;Hanson L;Ostergaard M. Dynamic gadolinium-enhanced magnetic resonance imaging allows accurate assessment of the synovial inflammatory activity in rheumatoid arthritis knee joints: a comparison with synovial histology. Scand J Rheumatol 2012, 41(2), 89-94. WebSearch

Hanson LG. Tools and methods for teaching magnetic resonance concepts and techniques. European Medical Physics News, Summer 2012, p. 17-19, 2012. PDF

Hanson LG. An active learning approach to education in MRI technology for the biomedical engineering curriculum. 11th Active Learning in Engineering Education Workshop (ALE), 2012. PDF

Hanson LG. MRI safety in practice: The EU directive on work in electromagnetic fields – practical and clinical aspects. ISMRM Safety workshop, syllabus contribution, 2012. PDF

Vestergaard MB;Schulz J;Turner R;Hanson LG. Motion tracking from gradient induced signals in electrode recordings. Proc of the ESMRMB 28th Annual Meeting, 368, 2011. WebSearch

í Dali C;Hanson LG;Barton NW;Fogh J;Nair N;Lund AM.  Brain N-acetylaspartate levels correlate with motor function in metachromatic leukodystrophy. Neurology 2010, 75(21), 1896-1903. WebSearch

Hanson LG. MR-skanning ved 7 tesla feltstyrke etableres i Danmark. MTI - Medicinsk Teknologi & Informatik, 4(7), 21-22, 2010. PDF | WebSearch

de Nijs R;Miranda MJ;Hansen LK;Hanson LG. Motion correction of single-voxel spectroscopy by independent component analysis applied to spectra from nonanesthetized pediatric subjects. Magn Reson Med 2009, 62(5), 1147-1154.  PDF | WebSearch

Hanson LG. Is quantum mechanics necessary for understanding magnetic resonance? Concepts in Magnetic Resonance Part A 2008, 32A(5), 329-340. PDF | WebSearch

Hanson LG. A graphical simulator for teaching basic and advanced MR imaging techniques. Radiographics 2007, 27(6), e27. PDF | WebSearch

Hanson LG;Lund TE;Hanson CG. Encoding of electrophysiology and other signals in MR images. J Magn Reson Imaging 2007, 25(5), 1059-1066. PDF | WebSearch

Mathiesen HK;Jonsson A;Tscherning T;Hanson LG;Andresen J;Blinkenberg M;Paulson OB;Sorensen PS. Correlation of global N-acetyl aspartate with cognitive impairment in multiple sclerosis. Arch Neurol 2006, 63(4), 533-536. WebSearch

Mathiesen HK;Nielsen AS;Nielsen K;Hanson LG. Magnetic resonance spectroscopy in the evaluation of cognitive disturbances. Ugeskr Laeger 2006, 168(4), 357-359. WebSearch

Nielsen K;Rostrup E;Frederiksen JL;Knudsen S;Mathiesen HK;Hanson LG;Paulson OB. Magnetic Resonance Imaging at 3.0 Tesla Detects More Lesions in Acute Optic Neuritis Than at 1.5 Tesla. Invest Radiol 2006, 41(2), 76-82. WebSearch

Sorensen PS;Jonsson A;Mathiesen HK;Blinkenberg M;Andresen J;Hanson LG;Ravnborg M. The relationship between MRI and PET changes and cognitive disturbances in MS. J Neurol Sci 2006, 245(1-2), 99-102. WebSearch

Hanson LG;Lund TE;Hanson CG. Encoding and transmission of signals as RF signals for detection using an MR apparatus. WO/2005/116676, PCT/DK2005/000343 2005. PDF | WebSearch

Mathiesen HK;Tscherning T;Sorensen PS;Larsson HB;Rostrup E;Paulson OB;Hanson LG. Multi-slice echo-planar spectroscopic MR imaging provides both global and local metabolite measures in multiple sclerosis. Magn Reson Med 2005, 53(4), 750-759. WebSearch

Stavngaard T;Søgaard LV;Mortensen J;Hanson LG;Schmiedeskamp J;Berthelsen AK;Dirksen A. Hyperpolarized 3He MRI and 81mKr SPECT in chronic obstructive pulmonary disease. Eur J Nucl Med Mol Imaging 2005, 32(4), 448-457. WebSearch

Born AP;Law I;Lund TE;Rostrup E;Hanson LG;Wildschiodtz G;Lou HC;Paulson OB. Cortical deactivation induced by visual stimulation in human slow-wave sleep. Neuroimage 2002, 17(3), 1325-1335. WebSearch

Andersen IK;Szymkowiak A;Rasmussen CE;Hanson LG;Marstrand JR;Larsson HB;Hansen LK. Perfusion quantification using Gaussian process deconvolution. Magn Reson Med 2002, 48(2), 351-61. WebSearch

Sager TN;Topp S;Torup L;Hanson LG;Egestad B;Moller A. Evaluation of CA1 damage using single-voxel 1H-MRS and un-biased stereology: Can non-invasive measures of N-acetyl-asparate following global ischemia be used as a reliable measure of neuronal damage? Brain Res 2001, 892(1), 166-75.

Hanson LG;Adalsteinsson E;Pfefferbaum A;Spielman DM. Optimal voxel size for measuring global gray and white matter proton metabolite concentrations using chemical shift imaging. Magn Reson Med 2000, 44(1), 10-18. PDF | WebSearch

Hanson LG;Schaumburg K;Paulson OB. Reconstruction strategy for echo planar spectroscopy and its application to partially undersampled imaging. Magn Reson Med 2000, 44(3), 412-17. PDF | WebSearch

Hanson LG, Zhang J, Lambropoulos P. Manifestations of atomic and core resonances in photoelectron energy spectra. Physical Review A 1997, 55(3), 2232-44. WebSearch

L. G. Hanson, J. Zhang and P. Lambropoulos, Theory of core-resonant ionization, Euro Phys Lett 1995, 30(2), 81-86.

Hanson LG, Lambropoulos P. Non-dispersing wave packets in two-electron atoms: Atomic mode-locking by loss modulation. Plysical Review Letters 1995. 74(25), 5009-12. WebSearch