Hartwig R. Siebner

Email

Tel.

+45 3862 6541

Position

Head of Research, Prof, DMSc

Affiliations

Department of Neurology, Copenhagen University Hospital Bispebjerg

Research Interests

Mapping and shaping causal dynamics in human brain networks:
My main interest is to study the causal dynamic interactions between brain regions in the human brain. I explore how these interactions support human brain function with a focus on motor control and decision-making. I combine advanced functional brain mapping techniques with interventions such as non-invasive transcranial brain stimulation (NTBS), training, or pharmacological manipulations. This "causal" research strategy allows me to identify and shape the network dynamics that determine human brain function in health and disease.

Pathogenesis and pathophysiology of brain disorders:
I use multimodal brain imaging to cast new light on the pathogenesis and pathophysiology of major brain disorders such as Parkinson ́s disease, multiple sclerosis, dystonia, Tourette syndrome, affective disorders, and schizophrenia. Adopting a pharmaco-fMRI approach, I identified an acute motor network response to levo-dopa therapy that predicted the emergence of medication-induced dyskinesia in patients with Parkinson´s disease.

Determinants of brain function and brain plasticity across the lifespan:
Another line of research is designed to identify structural or functional correlates in the brain that underlie behavioral traits and individual preferences. My neuroimaging research on handedness yielded important insights into how nature and nurture shape brain function and structure in the motor system.

Research Groups

Coordinator of the research area "Clinical Imaging"
Multiple Sclerosis (Group Leader)
Traumatic Brain Injury (Group Leader)
Motor Control (Group Leader)
Neurophysiology (Group Leader)
Movement Disorders (Group Leader)
As Head of Research, Hartwig is involved in all remaning research groups

Curriculum Vitae

Education

2000

Board Certified Neurologist

1990

Full Medical Licence

1989

Medical State Examination

1989

Study of Medicine, Med. Faculty, Johannes Gutenberg University, Mainz

1985

Study of Medicine, Med. Faculty, Saarland University, Homburg-Saar

Employments

2017 - Present

Full Professor for

2013 - Present

Head of Research, Movement Disorders Research, Department of Neurology, Copenhagen University Hospital Bispebjerg, Denmark

2012 - Present

Head of Research, Center for Functional and Diagnostic Imaging and Research (Includes DRCMR)

2010 - 2011

Head of Department, DRCMR, Copenhagen University Hospital Hvidovre, Denmark

2009 - 2017

Full Professor for

2008 - 2010

Consultant, DRCMR, Copenhagen University Hospital Hvidovre, Denmark

2004 - 2008

Full Professor for

2002 - 2008

Consultant, Dept. of Neurology, Christian-Albrechts-University (CAU), Kiel

2002 - 2002

Visiting Professor at Department of Brain Pathophysiology, Kyoto University, Japan

2000 - 2002

Post-doctoral Research Fellow at Sobell Department for Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK

1995 - 2000

Senior house officer, Dept. of Neurology, Munich University of Technology (TUM)

1992 - 1995

Senior house officer, Dept. of Neurology, St. Vinzenz-Hospital Paderborn

1990 - 1991

Medical officer, Dept. of Neurosurgery, Bundeswehrzentralkrankenhaus, Koblenz

1989 - 1990

Junior house officer (Arzt im Praktikum), Dept. of Internal Medicine, Mutterhaus Hospital, Trier, Special training in Oncology

Publications

Bergmann TO, Mölle M, Schmidt M, Lindner C, Marshall L, Born J, Siebner HR (2012). EEGguided TMS reveals rapid shifts in motor cortical excitability during the human sleep slow oscillation. J Neurosci. 32:243-53. 

Groppa S, Werner-Petroll N, Münchau A, Deuschl G, Ruschworth MF, Siebner HR (2012) Novel dual-site transcranial magnetic stimulation paradigm to prob fast facilitatory inputs from ipsilateral dorsal premotor cortex to primary motor cortex Neuroimage 62 500-9. 

Hartwigsen G, Bestmann S, Ward NS, Woerbel S, Mastroeni C, Granert O, Siebner HR (2012) Left dorsal premotor cortex and supramarginal gyrus complement each other during rapid action reprogramming. J Neurosci 32:16162-71. 

van Nuenen BFL, Kuhtz-Buschbeck J, Schulz C, Bloem BR, Siebner HR (2012) Weight-specific anticipatory coding of grip force in human dorsal premotor cortex. J Neurosci 32:5272-83. 

Hartwigsen G, Saur D, Price CJ, Baumgaertner A, Ulmer S, Siebner HR (2013) Perturbation of left posterior inferior frontal gyrus triggers adaptive plasticity in the right homologue during speech production. Proc Natl Acad Sci USA 110:16402-7. 

Kassuba T, Menz MM, Röder B, Siebner HR (2013) Multisensory interactions between auditory and haptic object recognition. Cereb Cortex 23:1097-1107. 

Macoveanu J, Rowe JB, Hornboll B, Elliott R, Paulson OB, Knudsen GM, Siebner HR (2013) Serotonin 2A receptors contribute to the regulation of risk-averse decisions. NeuroImage 83:35-44.

van der Vegt JPM, Hulme OJ, Zittel S, Madsen KH, Weiss MM, Buhmann C, Bloem BR, Münchau A, Siebner HR (2013) Attenuated neural response to gamble outcomes in drug-naive patients with Parkinson’s disease. Brain 136:1192-1203. 

Herz DM, Christensen MS, Bruggemann N, Hulme OJ, Ridderinkhof KR, Madsen KH, Siebner HR (2014) Motivational tuning of fronto-subthalamic connectivity facilitates control of action impulses. J Neurosci 34:3210-7.

Herz DM, Haagensen BN,Christensen MS, Madsen KH, Rowe J, Løkkegaard A, Siebner HR (2014) The acute brain response to levodopa heralds dyskinesias in Parkinson’s disease. Ann Neurol 75:829-36. 

Herz DM, Haagensen BN, Christensen MS, Madsen KH, Rowe JB, Løkkegaard A, Siebner HR (2015) Abnormal dopaminergic modulation of striato-cortical networks underlies levodopa-induced dyskinesias in humans. Brain 138:1658-1666.

Miskowiak KW, Vinberg M, Macoveanu J, Ehrenreich H, Køster N, Inkster B, Paulson OB, Kessing LV, Skimminge A, Siebner HR (2015) Effects of erythropoietin on hippocampal volume and memory in mood disorder: a randomized, placebo-controlled study. Biol Psychiat 8:270-277. 

Raffin E*, Pellegrino G*, Di Lazzaro V, Thielscher A, Siebner HR (2015) Bringing transcranial mapping into shape: Sulcus-aligned mapping captures motor somatotopy in human primary motor hand area. NeuroImage 120:164–175. * Shared first authors.

Angstmann S, Madsen KS, Skimminge A, Jernigan TL, Baaré WFC, Siebner HR (2016) Microstructural asymmetry of the corticospinal tracts predicts right-left differences in circle drawing skill in right-handed adolescents. Brain Struct Funct 221:4475-4489.

Bergmann TO, Karabanov A, Hartwigsen G, Thielscher A, Siebner HR (2016) Combining non-invasive transcranial brain stimulation with neuroimaging and electrophysiology: current approaches and future perspectives. NeuroImage 140:4-19.

Gaist D*, Grade E*, Blaabjerg M, Nielsen H, Krøigård T, Østergaard K, Settergren H,  von Bornemann Hjelmborg J, Madsen CG, Iversen P, Kyvik KO, Siebner HR, Ashina M (2016) MD, PhD, DMScMigraine with aura and risk of silent brain infarcts and white matter hyperintensities: A population-based MRI study of female Danish twins. Brain 139:2015-2023.

Gelskov SV, Madsen KH, Ramsøy TZ *, Siebner HR * (* equal contribution) 2016 Aberrant neural signatures of decision-making: pathological gamblers display cortico-striatal hypersensitivity to extreme gambles. NeuroImage 128:342-352. 

Karabanov A, Thielscher A, Siebner HR (2016) Transcranial brain stimulation: closing the loop between brain and stimulation. Curr Opin Neurol 29:397-404.

Løkkegaard A, Herz DM, Haagensen BN, Lorentzen AK, Eickhoff SB, Siebner HR (2016) Altered sensorimotor activation patterns in idiopathic dystonia - an activation likelihood estimation meta-analysis of functional brain imaging studies. Hum Brain Mapp 37:547-557. 

Macoveanu J, Fisher PM, Madsen MK, Mc Mahon B, Knudsen GM, Siebner HR (2016) Bright-light intervention induces a dose-dependent increase in striatal response to risk in healthy volunteers. NeuroImage 139:37-43.

Meder D, Madsen KH, Hulme O, Siebner HR (2016) Chasing probabilities - Signaling negative and positive prediction errors across domains. Neuroimage 134:180-191.

Meder D, Haagensen BN, Hulme H, Morville T, Gelskov S, Herz DM, Diomsina B, Christensen MS, Madsen KH, Siebner HR (2016) Tuning the brake while raising the stake: Network dynamics during sequential decision-making. J Neurosci 36:5417-5426.