The accompanying paper "Dynamic nuclear polarization and optimal control spatial-selective 13C MRI and MRS" describes the study in which Mads Sloth Vinding (Aarhus University) and Christoffer Laustsen (DRCMR and Aarhus University) used optimal control theory to design 2D spatially selective RF pulses. The method uses cleverly designed RF pulses that are applied together with modulated gradient waveforms to excite the magnetization only within a certain spatial area. As the front page image illustrates it was possible with this method to excite the letters "dnp" in a phantom containing hyperpolarized pyruvate. The method may provide means to establish highly sensitive and highly volume specific experiments for 13C metabolomic profiling in arbitrary detailed spatial regions.
Link to the JMR cover page
Link to the paper